 Â
Product Name: Apremilast (CC-10004)
Synonyms: ApreMilast;(S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide;ApreMilast,CC-10004;AcetaMide, N-[2-[(1S)-1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;Appleton West;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide Apremilast (CC-10004;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)
CAS: 608141-41-9
MF: C22H24N2O7S
Â
Apremilast Description
Â
Apremilast (Otezla) was approved by the FDA on March 21, 2014 for the treatment of adult patients with active psoriatic arthritis. Apremilast is a member of a new class of oral small molecule inhibitors of the phosphosphodiesterase 4 (PDE4) enzyme. When PDE4 is inhibited in immune cells, it results in elevation of intracellular cyclic adenosine monophosphate (cAMP) levels, which can regulate inflammatory mediators. The current clinical data indicate that apremilast is an effective and well tolerated option for the management of psoriasis and PsA in adults.
Apremilast Uses
Â
Treating active psoriatic arthritis. It is also used to treat moderate to severe plaque psoriasis in certain patients.
Â
Apremilast Metabolism and Drug interaction
Â
Oral administration of apremilast has an absolute biovailability of 73% with peak concentration at 2.5 hours (Tmax). The half-life of apremilast is 6-9 hours. Apremilast is metabolized by the both cytochrome (CYP) and non-CYP pathways. In vitro studies have demonstrated that apremilast metabolism is primarily mediated by the CYP3A4 pathway. Thus, concomitant use of apremilast with CYP450 enzyme inducers (such as rifampin, phenobarbital, carbamazepine, phenytoin) is not recommended. There are no significant drug-drug interactions with oral contraceptives, ketoconazole, or methotrexate.
Our advantange
Packing
Professional packing with professional materials, and We'll give clients several Packing way to choose after you contact me through my email
Quality
Our company is a professional leading factory in China in pharmaceutical area, ach batch of steroid powders have to tested by our QC(quality control) department before they are allowed to sell.
Delivery
We can pack your powders within 48 hours after your payment, and corresponding picture of your powders' parcel will be sent to you.
Price
Best prices you're sure to be satisfied, the more you buy, the more competitive prices you get.
Payment
T/T in advance, WU or Money Gram
 Â
Product Name: Apremilast (CC-10004)
Synonyms: ApreMilast;(S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide;ApreMilast,CC-10004;AcetaMide, N-[2-[(1S)-1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;Appleton West;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide Apremilast (CC-10004;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)
CAS: 608141-41-9
MF: C22H24N2O7S
Â
Apremilast Description
Â
Apremilast (Otezla) was approved by the FDA on March 21, 2014 for the treatment of adult patients with active psoriatic arthritis. Apremilast is a member of a new class of oral small molecule inhibitors of the phosphosphodiesterase 4 (PDE4) enzyme. When PDE4 is inhibited in immune cells, it results in elevation of intracellular cyclic adenosine monophosphate (cAMP) levels, which can regulate inflammatory mediators. The current clinical data indicate that apremilast is an effective and well tolerated option for the management of psoriasis and PsA in adults.
Apremilast Uses
Â
Treating active psoriatic arthritis. It is also used to treat moderate to severe plaque psoriasis in certain patients.
Â
Apremilast Metabolism and Drug interaction
Â
Oral administration of apremilast has an absolute biovailability of 73% with peak concentration at 2.5 hours (Tmax). The half-life of apremilast is 6-9 hours. Apremilast is metabolized by the both cytochrome (CYP) and non-CYP pathways. In vitro studies have demonstrated that apremilast metabolism is primarily mediated by the CYP3A4 pathway. Thus, concomitant use of apremilast with CYP450 enzyme inducers (such as rifampin, phenobarbital, carbamazepine, phenytoin) is not recommended. There are no significant drug-drug interactions with oral contraceptives, ketoconazole, or methotrexate.
Our advantange
Packing
Professional packing with professional materials, and We'll give clients several Packing way to choose after you contact me through my email
Quality
Our company is a professional leading factory in China in pharmaceutical area, ach batch of steroid powders have to tested by our QC(quality control) department before they are allowed to sell.
Delivery
We can pack your powders within 48 hours after your payment, and corresponding picture of your powders' parcel will be sent to you.
Price
Best prices you're sure to be satisfied, the more you buy, the more competitive prices you get.
Payment
T/T in advance, WU or Money Gram
COB Fine Pixel Pitch LED Display
Cob Led Display,Led Wall Pixel,Led Screen Pixel Pitch,Small Pitch Led Display
Shenzhen Apexls Optoelectronic Co., Ltd , https://www.apexls-display.com